Obesity and Breast Cancer: The Roles of Peroxisome Proliferator-Activated Receptor-gamma and Plasminogen Activator Inhibitor-1.

PPAR Res. 2009;2009:345320

Authors: Carter JC, Church FC

Breast cancer is the most prominent cancer among females in the United States. There are a number of risk factors associated with development of breast cancer, including consumption of a high-fat diet and obesity. Plasminogen activator inhibitor-1 (PAI-1) is a cytokine upregulated in obesity whose expression is correlated with a poor prognosis in breast cancer.

As a key mediator of adipogenesis and regulator of adipokine production, peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is involved in PAI-1 expression from adipose tissue. We summarize the current knowledge linking PPAR-gamma and PAI-1 expression to high-fat diet and obesity in the risk of breast cancer.

PMID: 19672469 [PubMed - in process]

Read more: pubmed: breast cancer