Tryptophan degradation in irritable bowel syndrome: evidence of indoleamine 2,3-dioxygenase activation in a male cohort.

BMC Gastroenterol. 2009;9:6

Authors: Clarke G, Fitzgerald P, Cryan JF, Cassidy EM, Quigley EM, Dinan TG

BACKGROUND: Irritable bowel syndrome (IBS) is a common disorder that affects 10-15% of the population. Although characterised by a lack of reliable biological markers, the disease state is increasingly viewed as a disorder of the brain-gut axis. In particular, accumulating evidence points to the involvement of both the central and peripheral serotonergic systems in disease symptomatology.

Total mesorectal excision for rectal cancer in an unselected population: quality assessment in a low volume center.

Int J Colorectal Dis. 2009 Aug;24(8):923-9

Authors: Ferenschild FT, Dawson I, de Wilt JH, de Graaf EJ, Groenendijk RP, Tetteroo GW OBJECTIVE: The aim of this study was to review the results and long-term outcome after total mesorectal excision (TME) for adenocarcinoma of the rectum in an unselected population in a community teaching hospital